How the Characters React Towards the Shooting of Candys Og Essay Example for Free

How the Characters React Towards the Shooting of Candys Og Essay The way the characters react towards the shooting of Candy’s dog reveals a lot abut the characters that we might not have expected. Carlson offers to shoot the old dog, complaining many times of the smell. The shooting of Candys dog shows the callousness of Carlson and the reality of old age and infirmity. Carlson typifies the men George describes as â€Å"the loneliest guys in the world†. He is outwardly friendly, but essentially selfish. He finds the smell of an old dog offensive so the dog must be shot. He shows very little regard to the dog’s owner, Candy. He relentlessly pursues the dog’s death, more for his own comfort than to put the dog out of its misery. However, Steinbeck does show some sympathy in Carlson, when he suggests â€Å"he won’t even feel it†, referring to Candy’s dogs death. This is contrasted to Candy’s procrastination to put this event off when he says â€Å"maybe tomorra, Le’s wait till tomorra† Steinbeck displays that Candy is trying to delay the put down of his dog and his reluctance to end his dogs life shows how much he loves the animal. â€Å"Carlson had refused to be drawn in† this suggest that Carlson is determined and not to be put off. When Carlson brutally keeps after candy, candy’s reaction is described in the adverbs Steinbeck has used: â€Å"uneasily,† â€Å"hopefully,† â€Å"hopelessly,† and the way candy reacts: â€Å"Candy looked for help from face to face.† When he reaches out to Slim for help, even Slim says it would be better to put the dog down. Slim is portrayed as serene and a good listener/observer in this novel, and when Steinbeck suggests â€Å"the skinner had been studying the old dog with his calm eyes† – referring to Slim, it suggests that he had been very thoughtful about the whole incident and even showed his understanding and considerateness when he reminded Carlson to take a shovel, so Candy will be spared the glimpse of the corpse. â€Å"I wisht somebody’d shoot me if I get an’ a cripple† are the words Slim uses that Candy later echoes when he considers his own future. This perceptibly puts Candy in deep thought, it shows Candy’s realisation of his own mortality when Slim states this. The dog, in this case tells us something of the owner. When Steinbeck shows the dog nearing the end of its days it could show that candy was too. Also Steinbeck employs irony by saying that he wanted someone to ‘shoot’ him when he got ‘old’ and ‘crippled’ which he almost is. Slim also reassures Candy when he says â€Å"you can have a pup if you want to†. When Candy finally gives in and allows Carlson to shoot his dog, it shows the reader that candy wants to be over and done with and wants his dog a swift and painless death. There is some empathy shown when Carlson says â€Å"come on boy† to soften the blow for the dog and more so Candy. Once Carlson has taken the dog to shoot, Steinbeck builds the tension within the characters just before the dog is killed. â€Å"George followed to the door and shut the door† – this proposes George’s kind nature and sympathy towards Candy and his dog- this could be one reason as to why George did not give an opinion on whether Candy’s dog should be shot. When George offers â€Å"anybody like to play a little euchre† it is evidently shown that George is trying to change the topic and he doesn’t want to worry Candy about the dog, this makes the reader see George taking people’s emotions into account before his own, we also saw this earlier in the book when George stands up for Lennie. We see this again when George â€Å"ripple the edge of the deck nervously† this shows that he is also concerned about the whole situation. It is evident that whit also showed concern indirectly when he says â€Å"what the hell is taking him so long†. When Steinbeck repeats â€Å"a minute passed, and another minute† he purposely extends the sentence which is a reflection as it prolongs the moment. And then when Steinbeck says â€Å"the silence came into the room. And the silence lasted.† Steinbeck employs short length sentences which make the moment seem longer and intensify the significance of that specific time. After â€Å"the shot sound in the distance† we are told that Candy â€Å"slowly rolled over and faced the wall and lay silent†, this reaction suggests that candy tried to bravely take in what just happened by turning his back to it and attempting to keep unruffled. The use of short sentence shows us that initially after the shot, there were no comments by anyone which implied that it left them in shock and the realisation of what just happened was slowly sinking in everyone’s head. Steinbeck’s employment of repetition of conjunctions with ‘and’ lengthens the sentence at the end, expanding the climax of the scene, as the audience wants to know what happened to Candy, after his most beloved companion has gone. Carlson even cleans his gun in front of Candy after the deed is done, this reinforces his brutal character. While it may be true that killing the dog put it out of its misery, little concern is shown for Candys feelings after a lifetime of caring for the dog. Now Candy is like the rest of them — alone.

Anti-inflammatory Function of Gut Macrophages

Anti-inflammatory Function of Gut Macrophages Colonic mucosa is a very peculiar immunological site daily exposed to a huge amount of harmless antigens. It is important for the immune system to be able to recognize this innocuous antigens from pathogens. Among all the immune cells, CX3CR1+ macrophages exploit this critical role. In this commentary on our recent publication on Immunobiology (Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages(1)we want to highlight the crucial and unique role of these macrophages in order to maintain homeostasis and avoid the rise of aberrant inflammation and tissue damage. The intestine is an exclusive tissue able to maintain balance between the immune system activation and the tolerance against the very huge amount of harmless antigens that are in contact with the intestinal lumen, including food antigens and microflora. It is fundamental for our health that our immune system is able to respond with a robust and appropriate response to potential dangerous antigens; but the same reaction against harmless antigens, like commensal bacteria or dietary proteins, could be very dangerous and could give rise to allergies or chronic inflammation that, in the end, can lead to tissue damage or cancer development. Many immune cells participate to the maintenance of the homeostasis in gut, with the role of understanding how an antigen is a potential danger for the organism and being silenced in response to commensal bacteria and food antigens. This complex landscape includes T and B lymphocytes, natural killer cells, innate lymphoid cells, eosinophils and mononuclear phagocytes: dendritic cells and macrophages. Among the latter, monocyte-derived macrophages, expressing the CX3CR1 receptor, constitute the most abundant population (2). The manuscript by Marelli et al., is focused on the role of CX3CR1+ macrophages in both steady state and acute colitis. In the last few years intensive research has been performed in order to clarify the role of these immune cells in the maintenance of homeostasis, but still, contrasting results have been reported regarding their role in the control of inflammatory response in the intestine (3,4). Considering this confused landscape, our paper aimed to clarify the role of CX3CR1+ cells in the development of acute colitis. By using mice lacking the receptor (CX3CR1GFP/GFP mice) we demonstrated that the absence of CX3CR1 on gut macrophages leads to a more severe degree of DSS-induced colitis, higher colon infiltration of inflammatory macrophages and Th17 lymphocytes and higher expression of inflammatory cytokines. Macrophages in the intestinal mucosa are considered mononuclear phagocytes that originate from a common myeloid progenitor which can differentiate also into dendritic cells (5). In contrast to others resident macrophages, they are continuously replenished from blood stream Ly6C+ monocytes, independently from the CX3CR1 receptor (6). This issue caused considerable misunderstanding in the past, generating the belief that these cells were dendritic cells (7,8). However, today it is recognized that Ly6Chi monocytes are recruited in the mucosa and there, in few days, they differentiate in mature macrophages, progressively loosing Ly6C and starting to express typical markers, such as F4/80, CD64, MHCII and CX3CR1 (6). As highlighted before, different authors investigated the role of CX3CR1+ gut macrophages with controversial outcomes. CX3CR1+ macrophages are supposed to maintain homeostasis in the gut (9). In accordance with this concept, our data revealed an exacerbated intestinal inflammation with a huge accumulation of macrophages in CX3CR1-KO mice. As reported also by different authors, (3,10) the natural consequence of the accumulation of macrophages is an increased production of cytokines, and hence a higher recruitment of immune cells in the colon, in particular T lymphocytes of the Th17 subset. On the contrary, other authors (4) suggested that the lack of the receptor impairs macrophages accumulation in the lamina propria. Moreover they suggested that the engagement of the receptor by its unique ligand (Fracktalkine/CX3CL1) resulted in an intensification of iNOS production, an inflammatory enzyme. Our data, instead, clearly demonstrate that the absence of the receptor increases the level of iNOS and of many other pro-inflammatory cytokines. This is a tissue-specific competence of the intestine, being colon ic resident macrophages an exemption from the rules. Indeed, in other tissues, the expression of CX3CR1 receptor is associated with a pro-inflammatory phenotype (11,12). In support of our data it is important to underline that, in the gut, CX3CR1 macrophages are fundamental to bring antigens and present them to DC in order to establish oral tolerance. When this mechanism is missing due to the lack of the receptor, the immune system is activated and this results in an acute inflammatory response (8). We have shown in Marelli et al. that if the CX3CR1 receptor is lacking, the ability of these cells to control inflammation is lost. Of note, CX3CR1-KO macrophages try counter-balance this aberrant situation by producing more IL-10, a major immune-suppressive and anti-inflammatory cytokine. In spite of this increase, IL-10 is not sufficient to control the inflammatory disease and mice have an exacerbated colitis. Overall, with our study we wanted to propose a definitive protective and anti-inflammatory role of CX3CR1+ macrophages during the processes of acute colitis; this concept may shed light also on the role of these cells in other pathological conditions of the gut associated with persistent inflammation. Our study established that macrophages expressing the functional CX3CR1 receptor have a non-redundant role in the control of aberrant intestinal inflammation, a harmful condition that may lead to tissue injury. CX3CR1 receptor expressed on intestinal macrophages is able to control colitis, avoiding the rise of aberrant inflammation. When the receptor is missing, the balance in the gut is broken, leading these cells to produce a huge amount of cytokines. Feeling the higher level of inflammation, CX3CR1 macrophages attempt to limit it by producing more IL-10, however this is not sufficient and the result is a higher accumulation of inflammatory Th17 lymphocytes and increased tissue injury.

Leadership and Management :: Business and Management Studies

In a firm, management and leadership are important and needed. Leadership and management are similar. Actually, leadership and management are totally different. The leadership would influence the firm. The leader would have difference leadership styles to lead the subordinate. The manager has different functions, attributes and skills. Different subordinate needs to have different leadership style. Finally, difference powers would have difference use on leadership influence. MANAGEMENT DEFINED Management can be defined as the process of planning organising, directing, and controlling organisational resources in the pursuit of organisational goals. LEADERSHIP DEFINED Leadership is frequently defined as a social influence relationship between two or more persons who depend on each other to attain certain mutual goals in a group situation. STYLES OF LEADERSHIP An autocratic leadership style is one where the manager sets objectives, allocates tasks, and insists on obedience. Therefore the group becomes dependent on him or her. The result of this style is the members of the group are often dissatisfied with the leader. This results in little cohesion, the need for high levels of supervision, and poor levels of motivation amongst employees. A democratic leadership style encourages participation in decision making. Democratic leadership styles can be persuasive or consultative. Persuasive – this is where a leader has already made a decision, but takes the time to persuade others that it is a good idea. Consultative – this is where a leader consults others about their views before making a decision. The decision will take into account these views. A laissez-faire type of leadership style allows employees to carry out activities freely within broad limits. The result is a relaxed atmosphere, but one where there are dew guidelines and directions. This can sometimes result in poor productivity and lack of motivation as employees have little incentive to work hard. Autocratic leaders centralize power and decision making in themselves. They structure the complete work situation for their employees, who are expected to do what they are told and not think for themselves. The leaders take full authority and assume full responsibility. Autocratic leadership typically is negative, based on threats and punishment, but it can appear to be positive, as demonstrated by the benevolent autocrat who chooses to give some rewards to employees. Consultative leaders approach one or more employees and ask them for inputs prior to making a decision. These leaders may then choose to use or ignore the information and advice received, however. If the inputs are seen as used, employees are likely to feel as though they had a positive impact; if the inputs are consistently rejected, employees are likely to feel that their time has been wasted. Participative leaders clearly decentralize authority. Participative decisions are not unilateral, as with the autocrat, because they use

Reasons the Moon Landings Could Be a Hoax Essay -- neil armstrong, nasa

â€Å"Every sight in space is spectacular.† This was said by Neil Armstrong, the first man to supposedly land on the moon. The question is, did he really land on the moon, or was it a broadcasted fraud? Thousands of Americans argue that it was a setup such as the attacks on September 11, and every day, somebody changes their opinion on what really happened. For many years, people have been trying to figure out this occasion, and ever since Neil Armstrong, Michael Collins, and Buzz Aldrin Ventured down from the moon, conspiracies have been appearing. The three men traveled on a ship called the â€Å"Eagle†. Facts show that Buzz Aldrin and Neil Armstrong were the only two to land, while Michael Collins orbited the moon. Neil Armstrong was the first person to step on the moon, saying his famous quote, â€Å"One small step for man, one large step for mankind.† Neil’s landing will be proved through many facts about the imprints on the moon, stories of these ast ronaut’s journeys, and situations that these men were actually in. What is the truth? Well, you are about to find out. Neil Armstrong was a boy scout as a young boy. He first flew in an airplane at age 6 interesting him enough to pursue in aerospace engineering to graduate from Purdue University. He eventually served in the air force as a pilot during the Korean War allowing him to become an astronaut for NASA. He was hoping to work at NASA in the future and have a chance to go to space. Armstrong did not expect to go to space, but when the opportunity came, he took it within a heartbeat. Neil Armstrong wasn’t the only person to land on the moon, Michael Collins and Buzz Aldrin joined Neil on this treacherous journey. These men have hundreds of interviews combined proving that they landed ... ...d 1. "10 Reasons the Moon Landings Could Be a Hoax." Listverse. N.p., n.d. Web. 06 Apr. 2014. 2. "Space and NASA News – Universe and Deep Space Information Space.com." Space.com. N.p., n.d. Web. 07 Apr. 2014. 3. Dun. "NASA." NASA. N.p., n.d. Web. 07 Apr. 2014. 4. "Top 5: Proofs That The Moon Landing Happened." AskMen. N.p., n.d. Web. 08 Apr. 2014. 5. NASA, Photograph Courtesy. "Photos: 8 Moon-Landing Hoax Myths--Busted." National Geographic. National Geographic Society, 16 July 2009. Web. 08 Apr. 2014. Books: (Alphabetized by Author’s last name) 1. Collins, Michael. Carrying the Fire; an Astronaut's Journeys. New York: Farrar, Straus and Giroux, 1974. Print. 2. Cortright, Edgar M. Apollo Expeditions to the Moon. Washington, DC: Scientific and Technical Information Office, National Aeronautics and Space Administration, 1975. Print.

Essay --

1. The 4 most important technological developments were round-hulled sailing ships, the compass, and improved map-making innovations, and knowledge of explosives/gunpowder weapons. These round-hulled ships allowed for further voyages into the Atlantic Ocean and for being able to carry large amounts of goods to trade in other places. The compass gave European’s the navigation tool they always needed to insure the y were going the correct way, allowing for more daring voyages to take place. Improved map making innovations also gave the Europeans a better idea of where they were and gave more confidence for more exploring and traveling to trade in distant lands. Finally gunpowder weapons gave Europeans the military advantages they needed over all the other civilizations in the world and allowed them to come and take port cities or entire civilizations. 2. Hongwu made notable reforms to the scholar-gentry influence and developed ways to check the abuses of other factions. He also tried to get more loyal bureaucrats by adding public beatings for disloyal or corrupted officials. In the first few years of the Ming dynasty, an economic boom happened as China began to contact other civilizations overseas. Population boom also occurred due to introduced crops from the Americas such as maize and potatoes. The merchant class became very wealthy off the economic boom and used their wealth to purchase land, increasing their social status. Chinese expansion occurred at a rate that a never been seen before. The Chinese began to push further out of Central Asia. The main motives for this were to explore other lands and to spread the glory of the Ming Empire. 3. Europeans Americas Cows Potatoes Horses Maize Diseases Sweet potatoes Onions Peanut... ...n put Confucian Scholars at the top and tried to cast aside anything other than Confucian thinking. Hindus became under attack by Mughal leaders that wanted to convert more to Islam. As he Mughals kept pushing deeper into India, tensions heated up as more people converted from Hinduism to Islam. After Newton published his book, it showed of a universe with simple laws and rules. It used rational hypothesis and generalization. It relied less on blind traditions of religious faith. Soon writers affected by the new science, although not scientist, began to attack traditional religious ideas such as miracles. Political change was complicated due to the absolute monarchy that arose in France vs the parliamentary monarchy that arose in England and Holland. These more effective central governments helped Europeans catch up in political forms that had been developed before

This is Water Summary Essay

Wallace delivered the Kenyon College commencement address that was not the typical commencement address you would normally hear at a graduation. He starts off his speech by telling a story having the idea that even the most â€Å"important realities are often the ones that are hardest to see and talk about. † He talks about living in the adult world that these soon to be graduates will enter and how it can be ere dull at times.And how learning about how to think about the choice we make in our life, the choices we make will impact our life whether it be a good impact, or a bad impact. Wallace delivers this speech (in a way to get these graduates not necessarily discouraged) giving the former students a face of reality that life is dull when you go through the same thing every day. And that when people go through the same thing â€Å"day in and day out† people tend to forget about the others around us.When forgetting about the other people around us occurs, Wallace belie ves that makes us believe that we are the â€Å"center of the universe. † This way of thinking as Wallace states is to be our â€Å"default setting† where we tend to block everyone our except for ourselves and if anyone gets in our way, then they must the ones at fault. Wallace also states, â€Å"if you really learn to pay attention, then you will know there are other options. † We have the choice to think of those other options, but we also have he choice to not think of those other options.Choosing the option to pay attention to the others around us and not be a â€Å"prisoner of our own brain† could possibly let ourselves live happier lives. Having awareness as Wallace stated, † Is unimaginably hard to do this, to stay conscious and alive In the adult world day In and day out. But, your education really Is the Job of a lifetime. † In conclusion, Wallace believes that we have choices to be aware of and to really think of the choices we make.

Overview of the organization of Wal-Mart Essay

Today, one of the most common places known to everyone (Except Paris Hilton) is Wal-Mart. Last year, Wal-Mart had revenues of $191 billion and has 1,283,000 employees, as of 2002. Wal-Mart is the largest retail store in the United States, and is larger than any other retail chain in the world. Currently Wal-Mart operates over 4,150 retail facilities globally. According to the Fortune 500 index of the wealthiest and most powerful corporations in the world, Wal-Mart holds the number one spot, ranked by its total sales. The company is ranked as the second most admired company in the world by Fortune (www.fortune.com). With all these numbers, you would think they had a long drawn out plan with goals as long as their success, but when Sam Walton created Wal-Mart in 1962, he declared that three policy goals would define his business: respect for the individual, service to customers, and striving for excellence (www.walmart.com). Three very short, but successful goals, which have been worki ng since. As I researched goals and planning, Wal-Mart’s goals are not the standard goals that I found. In the textbook there is information concerning characteristics of goals. Characteristics of Well-Designed Goals: 1) Written in terms of outcomes rather than actions. 2) Measurable and quantifiable. 3) Clear as to a time frame. 4) Challenging yet attainable. 5) Written down. 6) Communicated to all necessary organizational members. Management (Page 166 Para. 1) As we redirect to Wal-Marts goals, we can see that they would not be defined as well designed. Not many of the six characteristics would fit Sam Walton’s goals. 1) Respect for the individual – This could not be considered for outcomes rather than actions nor is it measurable and quantifiable. It contains no time frame and I hardly consider respect as a challenge. However the goals were written and have been communicated to all employees. When it comes to the respect from Wal-Mart stores many individuals feel Sam Walton has lost his sight. I researched what others had to say about the goals. â€Å"Everyone says the store really got bad after Sam died,† one individual explains. http://members.aol.com/walmopboy/abuse/strl.htm (Look Before You Leap) The site contains articles customers and employees have posted about the treatment they have received at various Wal-Mart stores. 2) Service to customers – Once again this fits only the last two characteristics explained. It is written and has been communicated. 3) Striving for excellence – This, compared to the other two fits the characteristics best. It could be considered for outcomes rather than action, and could be considered challenging. It is not measurable and quantifiable, nor clear as to a time frame. However, it is once again written down and communicated to the employees. When I researched how well these goals were communicated to the employees, I found that they are printed on the hiring paperwork. Once the paperwork is complete the employees do not see or receive the goals. Therefore, I do not feel the goals are communicated effectively among the employees and organization. In order for the goals to be achieved, I feel the employees must be aware of Sam Walton’s sight. I believe the first step to achieve these goals effectively would be to instill them within the employees. They should be explained clearly and constantly. They should also be printed, in clear sight. This would help to  remind employees and show customers their attitudes. I also feel that the goals should have a clear time frame and measurable. For example: In one year, cut complaints to less than 20 per store. There should be some way to ensure the goals are being reached. By setting time frames and a measurable form the store can see how well or terrible they are doing. Resources: 1) Wal-Mart Homepage http://www.walmart.com/ [Accessed 18 July 2004] 2) Fortune http://www.fortune.com/fortune/ [Accessed 18 July 2004] 3) Wal-Mart Horror Stories – Archives http://members.aol.com/walmopboy/abuse/strl.htm [Accessed 19 July 2004] 4) Robbins, Coulter (2005) Management Eighth Edition Upper Saddle River, NJ: Pearson Custom Publishing