My aim is to investigate Borders Essay Example

My aim is to investigate Borders Essay My aim is to investigate Borders. I will be drawing borders to different squares and finding a formula for each one and finally I will find a Universal Formula. Introduction This is what the task tells me: Here are 2 squares with squares added on each side to make a border, which surrounds the starting squares. We will write a custom essay sample on My aim is to investigate Borders specifically for you for only $16.38 $13.9/page Order now We will write a custom essay sample on My aim is to investigate Borders specifically for you FOR ONLY $16.38 $13.9/page Hire Writer We will write a custom essay sample on My aim is to investigate Borders specifically for you FOR ONLY $16.38 $13.9/page Hire Writer You can then add another border as shown: Investigate Borders. Method First I will find out how many squares needed for the border to a 11 square, then 21 and so on up to 51. Then I will find a formula for the border to each square and also test the formula out to prove that it works. I will predict how many squares needed for the 6th border and find out if my prediction was correct. Next, I will find out how many squares needed for the border of a 12 square, then 22, and so on up to 52, then 13, 23, and so on up to 53. Again I will find formulas to them and prove that all the formulas work. Finally, I will put all the formulas together in three groups and find one overall formula for each of the groups. Then, I will get those three formulas and get one Universal formula in the end. Diagram of Borders of square: 11 Table of results for Borders of square: 11 Formula You can always find the nth term using the Formula: a is simply the value of THE FIRST TERM in the sequence. d is simply the value of THE COMMON DIFFERENCE between the terms. To get the nth term you just need to find the values of a and d from the sequence and stick them in the formula. Formula to find the number of squares needed for each border (for square 11): Common difference = 4 First term = 4 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 = 24 Common Difference nth Term Results My prediction was 24 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Diagram of Borders of square: 21 Table of results for Borders of square: 21 Formula to find the number of squares needed for each border (for square 21): Common difference = 4 First term = 6 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 2 = 26 Common Difference nth Term Results My prediction was 26 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Diagram of Borders of square: 31 Table of results for Borders of square: 31 Formula to find the number of squares needed for each border (for square 31): Common difference = 4 First term = 8 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 4 = 28 Common Difference nth Term Results My prediction was 28 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Diagram of Borders of square: 41 Table of results for Borders of square: 41 Formula to find the number of squares needed for each border (for square 41): Common difference = 4 First term = 10 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 6 = 30 Common Difference nth Term Results My prediction was 30 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Diagram of Borders of square: 51 Table of results for Borders of square: 51 Formula to find the number of squares needed for each border (for square 51): Common difference = 4 First term = 12 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 8 = 32 Common Difference nth Term Results My prediction was 32 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Formula to find the number of squares needed for each border (for square 12): Formula = Simplification = I have already found out the Formula for 12 so theres no need for the Diagrams ; Tables, and I have already proved that the Formula works. Diagram of Borders of square: 22 Table of results for Borders of square: 22 Formula to find the number of squares needed for each border (for square 22): Common difference = 4 First term = 8 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 4 = 28 Common Difference nth Term Results My prediction was 28 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Diagram of Borders of square: 32 Table of results for Borders of square: 32 Formula to find the number of squares needed for each border (for square 32): Common difference = 4 First term = 10 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 6 = 30 Common Difference nth Term Results My prediction was 30 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Diagram of Borders of square: 42 Table of results for Borders of square: 42 Formula to find the number of squares needed for each border (for square 42): Common difference = 4 First term = 12 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 8 = 32 Common Difference nth Term Results My prediction was 32 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Diagram of Borders of square: 52 Table of results for Borders of square: 52 Formula to find the number of squares needed for each border (for square 52): Common difference = 4 First term = 14 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 10 = 34 Common Difference nth Term Results My prediction was 34 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Formula to find the number of squares needed for each border (for square 13): Formula = Simplification = As before, I have already done the working out for this Formula and it has been proved. Formula to find the number of squares needed for each border (for square 23): Formula = Simplification = Again the working outs been done. Diagram of Borders of square: 33 Table of results for Borders of square: 33 Formula to find the number of squares needed for each border (for square 33): Common difference = 4 First term = 12 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 8 = 32 Common Difference nth Term Results My prediction was 32 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Diagram of Borders of square: 43 Table of results for Borders of square: 43 Formula to find the number of squares needed for each border (for square 43): Common difference = 4 First term = 14 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 10 = 34 Common Difference nth Term Results My prediction was 34 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. Diagram of Borders of square: 53 Table of results for Borders of square: 53 Formula to find the number of squares needed for each border (for square 53): Common difference = 4 First term = 16 Formula = Simplification = Experiment I will try to find the number of squares needed for border number 6 using the formula, I found out, above: nth term = 4 x 6 + 12 = 36 Common Difference nth Term Results My prediction was 36 which is the correct answer, for the number of squares needed for border number 6, and which also proves that the formula is in working order. The overall formula to the borders of nx1: 11 = 4n 21 = 4n + 2 31 = 4n + 4 41 = 4n + 6 51 = 4n + 8 Formula for nx1th term: 4 y + ( 2 n 2 ) e.g. for border number 6: First replace n with 6. 4 y + ( 2 x 6 2 ) = 4 y + 10 Now you can replace the y with an n to have the formula, to find the number of squares, for border number 6. 4 n + 10 The overall formula to the borders of nx2: 12 = 4n + 2 22 = 4n + 4 32 = 4n + 6 42 = 4n + 8 52 = 4n + 10 Formula for nx2th term: 4 y + ( 2 n ) e.g. for border number 6: First replace n with 6. 4 y + ( 2 x 6 ) = 4 y + 12 Now you can replace the y with an n to have the formula, to find the number of squares, for border number 6. 4 n + 12 The overall formula to the borders of nx3: 13 = 4n + 4 23 = 4n + 6 33 = 4n + 8 43 = 4n + 10 53 = 4n + 12 Formula for nx3th term: 4 y + ( 2 n + 2 ) e.g. for border number 6: First replace n with 6. 4 y + ( 2 x 6 + 2) = 4 y + 14 Now you can replace the y with an n to have the formula, to find the number of squares, for border number 6. 4 n + 14 The Universal formula: The formula for Length x Width = 4 n + 2 L + 2 W 4 = B (Border) e.g. for the 6th border of a 53 rectangle: First replace n with the border number = 6, L with the Length = 5, and W with the Width = 3. Then add brackets where necessary. ( 4 x 6 ) + ( 2 x 5 ) + ( 2 x 3) 4 = B Then multiply out the brackets: 24 + 10 + 6 4 = 36 36 is the correct answer. Formulas for nx1 11 = 4n 21 = 4n + 2 31 = 4n + 4 41 = 4n + 6 51 = 4n + 8 Formulas for nx2 11 = 4n + 2 21 = 4n + 4 31 = 4n + 6 41 = 4n + 8 51 = 4n + 10 Formulas for nx3 11 = 4n + 4 21 = 4n + 6 31 = 4n + 8 41 = 4n + 10 51 = 4n + 12 Conclusion In the time available to me, I believe I have researched Borders to the full extent of my ability. I found formulas to squares nx1. I then extended this to squares nx2 and nx3, and I then was able to construct my Universal Formula, which will tell you the number of squares in any border of square nxn, which could be anything from 22 to 1015. I also found that many of my predictions I made along the way turned out to be correct. I would say that this investigation has been a success. I began this investigation with the aim to find formulas to nx1, nx2 nx3 and then a Universal Formula and they were achieved.

Comparitive Study of Two Multi National Corporations

Comparitive Study of Two Multi National Corporations Abstract Wal-Mart Company and London Cake Company are the chosen multinational corporations for this analysis. In analyzing the two companies, the main focus will be centered on how these multinational corporations differ in terms of the way they treat workers as well as employees from various countries. Under this analysis, the paper will also focus on the common practices and characteristics, which are relevant to these two multinational corporations.Advertising We will write a custom essay sample on Comparitive Study of Two Multi National Corporations specifically for you for only $16.05 $11/page Learn More Introduction It is evidenced that the main differences that are often witnessed in these two multinational corporations are gender inequalities among both the workers and the employees from different countries. In fact, the practices of gender inequalities and other socio-economic factors have really affected the productivity of both the Wal-Mart Compa ny and the London Cake Company. Gender discrimination is any form of unequal opportunity awarded purely based on sex of an individual. Social discrimination is any form of a move aimed at decreasing the status of a given gender in the social sphere of life. The most common social discrimination occurs to women. Gender discrimination among women is a form of an abuse, which lowers their dignity and capability in executing tasks to men. Differences analyzed There are more ways by which discriminations are experienced in the work place in the Wal-Mart Company. For instance, direct inequality happens when employer offers driving jobs to only male applicants. This is gender discrimination practiced among the employees and workers. There are also indirect discrimination cases where the given work conditions only favour one group of people. Women are forced to work until late and even overtime irrespective of any domestic responsibility that they might have (Drucker 29). Harassment of any kind is a way of reflecting inequality at the work place. This mainly takes place in the offices or dinners held by the company for the employees, most of which are sexual harassment. In addition, victimization at work place is rampant. The employer might favour one person of the opposite sex based on personal interest. Treating a person unfairly also amounts to discrimination at work. This mainly happens to employees who are ignorant of their rights. It should to be admitted that some employees at the Wal-Mart Company felt inequality based on gender or race (Hamel 79).Advertising Looking for essay on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More Work place gender discrimination has been witnessed to be the most common form of bias in the social set up. People with the same academic qualification, experience, and competencies have been unethically given promotion and job opportunities based on their sex. Job d iscrimination can either be under the whole employees group or on individual basis. Following statistical evidences, women are the most discriminated in pay and promotion, although the trend is gradually changing. Women segregation on pay has also been witnessed to decrease in gap. Between 1990 and 2000, payment was increased by 75 percent for men and only 25 percent for women. Women are also given job opportunities based on childcare (Drucker 47). This has shown that most women only getting part-time jobs, while men get permanent employments. Women are also horizontally segregated in work place environments. The Wal-Mart Company has distinct types of positions, which women can occupy while the rest are perfectly design for men. It was indicated by 2001 that only 20 percent of women were managers in Wal-Mart stores. Men occupied the largest 80 percentage. The pay gap was at around 20 percent with women earning at 72.5 percent (Hamel 96). Attention of many people has been drawn towar ds the operation of this multinational corporation on its sexism strategies. Wal-Mart Company has been seen in strings of gender based cases, especially in the Supreme Court. Most of this allegations are based on unequal treatment of women and men, especially on basis of promotion and payment policies. It has been an escalating task for the court to offer a verdict on this case, following the fact that the Company has a well-structured policy outline against any form of gender disparity. At the same time, the court has found it very hard to prove the allegations due to problems of evidence collection. Even though, many have doubted the possibility of Wal-Marts’ possibility of performing in the competitive market, it has been proven by several studies that the company has taken unhealthy approach towards the gender bias. Researches carried through interviews and questionnaires have shown that Wal-Mart Company created gender disparities both vertically and horizontally. In addi tion, the court cases pulling down this organization have brought out this clear picture.Advertising We will write a custom essay sample on Comparitive Study of Two Multi National Corporations specifically for you for only $16.05 $11/page Learn More Horizontal segregation has been noted by the fact that most of women across the branches of this organization work in almost similar departments. Men’s departments in the work places have shown that they were evenly distributed both in the department and positions. It was shown that large percentagesof administrative and management body were carried out by men. At the same time, men filled the supervisory portfolio as well as ranks, which are down the ladder. Most women in the Company are working at the level of secretary and sales. The percentage of women in the administrative and management system are hardly 25 percent today in this Company. It can be proven that the criteria are not purely based on job qualification as women respondents believed some of them were holding if not equal then above in credentials. Vertical segregation is the biggest challenge in an organization operating like Wal-Mart. Vertical segregation occurs in a place, where the promotion aspect is being addressed in terms of grades and pay. Despite their grades and competencies, women tend to stay longer on low-level jobs as compared to men. This is majorly contributed the organization strategies rather than inefficiency among women. For those that manage to get promotions to the higher positions, they suffer the ‘glass ceiling effect’. The ‘Glass ceiling effect’ is where the women can get to the top only in theory while they cannot achieve it in practice. The speed of promotion is also noted to be higher among men as compared to women. This could be noted by the fact that job stagnancy is more in percentage among women as compared to men. Some women end up falling out of their jobs o ut of frustrations, while others seek judicial interventions. Pay gaps have been seen as another determinants of gender disparity in the Wal-Mart Company. It can be evidenced that many women seek aid from the court over their pay as compared to men. Men in this company feel satisfied with their pay and promotion according to women respondents. Pay in any work set up is tied to promotions and job ranks, thus women are generally disadvantaged in this multinational corporation. The pay gap between men and women is not that distinct on the employees on the same rank. However, the general pay gap is larger on men than on women.Advertising Looking for essay on business economics? Let's see if we can help you! Get your first paper with 15% OFF Learn More The gap is taken from the total some payable to equal number of employees of both sexes separately. A number of cases have been filed over the company, which includes poor remuneration policies among women, but the company has come to a great defense on its operation system. The gender segregation in Wal-Mart Company cannot be understood properly, as its own policies are clear and against any form of gender biasness. It was thought that gender issues affecting this company are local problems within the branches, but this has been disputed by the accumulating cases across the branches. Business organizations always have very objective management system. The system must have clear and sound strategies on the approach of challenges experienced. When these challenges are overturned, the company shall have better results, which translate to reasonable profit. This is why management is termed as a result oriented concept. Good human resource is very vital for the success of any system. Mo reover, this topic is useful to the company because it helps them have the analysis of their human resources and tackle the changes. The management strategies are also useful to ensure proper accountability and ways in which this can be improved. The other objective is to ensure a good strategic management to divert any eminent challenges in future so as to have a clear roadmap for the business. Analysis of major factors affecting the strategic management is looked at. The political and social environment can determine the productive nature of the organization’s performance. Economic factors can be described as the market stabilities, which are affected by either inflation or deflation. Presentation of literature captures on these categories such as environmental analysis, competitive strategies, human resource challenges, organizational behavior, leadership roles, and other employees attendance incentive schemes. In the research study, the results obtained from the London Ca ke Company are very useful to the multinational corporation and any other related business organization. The company knew its competitors and applied these instrumental strategies, thus mobilized their market share. It is through this that they were able to capture the market and have large sales. They also knew that food industry is an investment that will never fall, especially when one goes with the emerging trends in the market. The multi-corporation also applied technology in their strategy. Technology played a major role in this company. The London Cake Company Limited opened a web site. This site was able to attract many people, especially those who even never knew about their products. Customers accessed them through the web. Through this, they have enhanced their marketing strategy to reach many people. The shape of their cakes is very appealing to the customers. This is one of their strengths. The main is the trends in the environment and their events. These have potential to affect the given strategy. The analysis is able to identify these events and trends plus being able to estimate their impact and chances. In performing this analysis, it is essential to limit the analysis to those places, which are relevant and can have considerable impact on the intended strategy. Environmental analysis has five categories, political, technological, economical, and sociological aspects. Political happens when the government has political good will, hence the regulations being put in place change business mode of operation. Like good policies and political good will to enhance business operation. These taxes and incentives can affect business strategy development. Technology determines what extent the existing technology to be effective. The company uses an advanced technology to enhance its products output. They have well equipped modern factory, which has enhanced production of more Cake products. Focusing on the economic aspect, the U K has a stable economy h ence this has ensured minimal cost of production and good supplies. The inflation or deflation is not realized in the company because of the stable economy. Socio-cultural reflects on the current emerging trends in the lifestyle since they were dealing in food industry, these products are really selling and they have a good market. The emerging trend in life style is that people really value cakes for their celebrations and general usage of the house. The ready market enables the company to expand rapidly because it is in line of its business strategy (Handy 46). HR challenges regarding the workers and employees of the Wal-Mart Company Human resource challenges are numerous in number because they are of different categories. The most important challenges are change managements in the business. The environmental HR challenges, workplace diversity, leadership development, retention and motivation or HR effectiveness measurement, compensation, and attracting the best talent. These ment ioned challenges and others are discussed effectively in the following paragraphs. In the Wal-Mart Company, workplace diversity is broader than the London Cake Company and its dimensions include age, gender, ethnicity, sexual orientation, physical abilities, race, educational background, geographic location, income, marital status, religious beliefs, parental status, and work experience. The company was able to deal with all the forms in the most professional way. The human resource manager introduced training on knowledge development based on utilization skills and continuous training to enhance individual competency. The company would never succeed without all these professional approaches towards the proper management and treatment of its employees (Lamb 57). In comparison to the London Cake Company, the treatment and management practices can be analyzed under the following paragraphs. The treatment of workers and employees of the London Cake Company Analyzed The London Cake Comp any observed that the average number of years or tenure for some professional employees is less than three years. This applies to IT professionals, marketers and other middle strategic managers. The company offers good remuneration to maintain its employees. There is also a problem of attracting the best talents. In a tensed job market, most organizations always experience concurrent demands to get the same kind of talented professionals. In their pursuit for talented employees, they end up cajoling talent all over the world. This company has designed ways of attracting these talents by knowing the reward factors contributing to this. An employee with good communication skills, with capacity to think logically and being able to be analytic coupled with excellent leadership qualities is of great importance to the organization. The London Cake Company never faced all these challenges. When these challenges are addressed, it will have certain implications. The company may offer to pay the required amount at the market demands, but the cost of operation is going to be raised rapidly. This has the effect of reducing the profit margin. For its effectiveness, the management should undertake regular assessments on all issues. These include pay, work environment, benefits, administration, and promotional opportunities to monitor the progress in long term basis. Appropriate tools for measuring development must also be put in place. Introduction of IT training to all the staff will be very effective and motivational to the employees of the London Cake Company Ltd (Asnoff 49). Government roles in terms of legislative and regulatory settings, monitoring and enforcing ethical policies The British government had formed a commission referred to as Equal Opportunities Commission. This commission is championing on unfair treatment of employees at the work place. The commission was formed in 1975 and is still active to date. In Wal-Mart, women on part-time employment are paid le ss by 38.4 percent as compared to men. Full time workers have a gap of 17.2 percent (Blaxill 19).This shows high level of inequality in Wal-Mart workplace. In the Wal-Mart Company, the government asked some of the independent bodies to investigate women harassment at the offices and even in the armed forces. In addition, around 30,000 workers lose their jobs in Wal-Mart because of being pregnant. Finally, many cases of sexual harassment and discrimination have been handed by the court system in the Wal-Mart. All these confirm that there is no equality in most of the working places (Boxall 23). Common Characteristics Retention and motivation of both the employees and workers can also be termed as HR effectiveness and measurement. Motivation and retention of personnel are â€Å"very difficult not only to the Wal-Mart Company, but also to the London Cake Company. It has become a general concern today† (Ansoff 74). In fact, the technological challenge affects both the human resou rces resources of both the Wal-Mart Company and the London Cake Company. This problem has really affected the management and treatment of the workers of these two multinational corporations. Technology is a very prominent item that can have either direct or indirect effect to any company. Technology provides better ways of management, when applied in the right way. It comes in various fields and specification required when dealing in any business transaction. Some computer software may develop technical problems and it only calls for an expert to correct. The company did not train all the employees and workers on computing issues. Only IT departments had the capacity. However, this was not crucial, as measures are underway to implement the policy that all the employees must be knowledgeable in basic computer skills. The purpose is to facilitate communication between the organization and the employees, which is crucial in solving conflicts on management and the treatment of the worke rs (Boselie 102). Conclusion In sum, it has been witnessed from the two multinational corporations, which have been analyzed above that they unfair treat both their workers and employees because they often practice gender inequality. This has been seen in the cases of both the Wal-Mart Company and the London Cake Company. These unfair practices in the employment set ups have prompted the British government to set up independent organizations to investigate the case of Wal-Mart Company. In fact, such unfair treatment of workers should be discouraged through strict laws and regulations so as to achieve success and growth among these two prominent multinational corporations. Blaxill, Mark, and Ralph Eckardt. The Invisible Edge: Taking your Strategy to the Next Level Using Intellectual property. London: Irvine Publishers, 2009. Print. Boselie, Peter. Strategic Human Resource Management: A Balanced Approach. Boston: McGraw Hill Higher Education Publishers, 2010. Print Boxall, Philip. Th e Oxford Handbook of Human Resource Management. Oxford: Oxford University Press, 2007. Print. Drucker, Peter. The Age of Discontinuity. London: Heinemann Publishers, 2004. Print. Hamel, Gary. Leading the Revolution. New York, NY: Plume Publishers, 2002. Print. Handy, Charles. The Age of Unreason. London: Hutchinson Publishers, 1989. Print. Igor, Henry. Corporate Strategy. New York, NY: McGraw Hill Publishers, 1965. Print. Lamb, Robert. Competitive Strategic Management. New Jersey, NJ: Prentice-Hall, 1984. Print.

Summarize chapter one Essay Example | Topics and Well Written Essays - 500 words

Summarize chapter one - Essay Example A network of packet switches and communication links work hand in hand with end systems since they are effectively connected together. Some of the communication links include optical fiber, radio spectrum and cooper wire and they are made up of different physical media types. This links differ since each one of them transmits data at different rates in bits/second. A route or path is referred to as a sequence at which packet switches and communication links are traversed by a packet from the sending end system to the receiving end system. A Services description defines the internet as an infrastructure which provides various services to different applications such as social networks, remote login and video streaming. An application Programming Interface helps in specifying how a program running on one end system asks the Internet infrastructure to deliver certain data to specific program running on another end system destination. By considering some human analogies, humans in all times, execute protocols in order to understand the notion of a computer network protocol. The actions taken by humans when they send or receive messages through the internet contributes to the practice of human protocol role. Different humans have got different protocols since they respond differently when they send or receive these messages. In network protocols, the entities used in exchanging messages and taking actions are software components like computers or hardware, unlike human protocols. A network protocol largely governs all activities in the internet which involve two or more entities in communicating remote. Through internet network connection, digital subscriber line (DSL), cable, Dial- up and satellite has been developed. For example a residence may obtain DSL Internet access from the same local telephone company which provides its local phone access that is wired. On the other hand, cable Internet access enhances us e of the cable television

Cell cycle by emphasizing DNA replication Research Paper

Cell cycle by emphasizing DNA replication - Research Paper Example Increase in the number of cells with 2C-DNA content attests that over expression of wild type CDC6 impacts on the cell cycle kinetics. However, this over expression has no effect on cell proliferation. After S phase is complete, CDC6-d2 on the other hand blocks cell cycle progression and inhibits proliferation as cells with 2C DNA pile up; CDC6-d2 does not inhibit DNA replication but it does passage via mitosis. When SCF CDC4 is inactive, dephosphorylation of B subunit can be driven by over expression of the wild type CDC6 in nocodazole arrested cells. This however is not the case as with when the SCF CDC4 is active as over expression of the cells does not lead to dephosphorylation of the B subunit because over expression of CDC6-d2 blocks cells in G2/M by inactivating CDC28-Clb kinase and in a CDC4+ background produces phenotype very much like that produced by the over expression of wild type CDC6 in a CDC4 mutant background. Unlike CDC6-d2 which is stable in nocodazole arrested cells, the wild type protein is not and quickly disappears into the cells thus showing CDC6-d2 as being resistant to mode 3 proteolysis. It is noted however that CDC6-d2 is not affected for mode 1 proteolysis or mode 2 proteolysis but is affected as a substrate for mode 3 proteolysis; a single point mutation yielding transformation from C to T at bp 1103 causing substitution of threonine at amino acid 368 with methionine was pointed out after DNA analysis of the CDC6-d2. There are three glycine and six proline residues in a 50 amino acid residue surrounding this region, triggering belief that this region could be unstructured (Perkins, Lusy & John, 4837). Two other regions were equally examined to check whether their muattions also had some effects on the stability of CDC6. Two CDC6 alleles were constructed using site directed mutagenesis where serine 372 was transformed to alanine (S372A) and in the other, serine 354 was changed alanine

Pharmacology Case Study Example | Topics and Well Written Essays - 1250 words

Pharmacology - Case Study Example A study by Peng et al. (2004) on Pharmacokinetics and Pharmacodynamics of Imatinib in a Phase I Trial with Chronic Myeloid Leukemia Patients, found confirmed the findings of Reckmann et al. (2002) that the drug is absorbed immediately it is administered orally. Further, when they compared imatinib with AUC0-24 hours at steady-state and on day 1, there was a 1.5- to 3-fold drug accumulation after the dose is repeated once a day. Killock (2014) has found that after administration of 350 mg of imatinib at a normal state, the mean plasma trough concentration records at 570 ng/mL and above (about 1 _mol/L). This plasma concentration is more than the 50% inhibitory concentration that successfully inhibits proliferation of BCR-Abl–positive leukemic cells gotten from CML patients (Mitzuta et al. 2013). With imatinib, the relationship between the white blood cells reduction and PK parameters at normal circumstances indicate that the initial imatinib’s hematologic response depend s highly on the dose administered to the CML patient and in this case, a dose higher than 400mg is needed in order to have an optimum effect on white blood cells reduction (Al Ali et al. 2002). From the above information, it is clear that the action of imatinib is therefore different and advanced as compared to the older therapies whose pharmacodynamics and pharmacokinetics are different and present chances of many side effects that in most cases lead to discontinuation of medication therapy.

Case study Human Social Behavior

Case study Human Social Behavior Introduction- This article is about the human behavior and the various factors which affects the human behavior. One of the factors that have a great impact on the behavior of human is the social environment and here all types of sociological effects are discussed. Various individual environmental factors and their impact on behavior are also discussed here. Inheritances also affects the human behavior and in this article two types of inheritances are discussed and that are cultural and the genetic inheritances. Nature and nurture both has impacts on the development of humans and nurture has some of the effects on behavior of humans. In the end of the article there is a detail discussion about the evolutionary thinking and the factors like psychological and the biological which changes the human behavior Body 1-7 Behavior of the human being decides the overall personality and this behavior of human are influenced by many factors like cultural, economic, and sociological. Human behavior is influenced by the most discussed effect that is the sociological effect. The most complex society of any creature on earth is of humans and it means self-preservation beyond the level of persona; physical survival is extended by us. Humans live in a very typical society in which there is bonding between the groups for the purpose of mutual and protection. Families, friendships, associations etc are included in these groups. Due to the formation of society and humans social links increases the bond between different people which is a human behavior. One of the bad behavior that every human being have is of greed and this behavior of human finishes them completely but due to society and links with different families and groups decreases the human greed of money or anything else. Due to increase of population a nd the urbanization, the people have started neglecting the social relationship and everyone is giving importance to the money rather than social relationship and behavior. Because of this, the rate of crime and deviant behavior of humans are found in cities. All these sociological effects have impacts on the behavior of the human beings and the social environment plays an important role in the development of the child which includes the attainment of full genetic and human potential. (Conklin, 2004) The biological and the psychological changes occurring in the human beings are basically during time period from birth and the end of adolescence. Genetic factors are the factors which are related to the genes of the child and also refer to the changes that occur at every point in growth. Social environment plays a very important role in the development of child and a new born baby do not experience any fear to contact with any specific people but after the time period of 8-12 months there is a change in them and they start to prefer the people who are familiar and also start showing the feelings like anxiety and distress when they are separated from their family members. Social environment helps the child to understand the social rules in the period of preschool and adulthood. The time period of middle childhood have the characteristics of friendship with age mates and also the beginning of romantic love. Another social effect on the child development is of bonding between the diffe rent groups of people and the idea of maintaining social relations develops in the child which helps him/her lifelong. There are various processes which are controlled genetically and they are known as maturation. Maturation is related to the mental and the physical development of the child and a child is said to be matured when he/she becomes capable of taking their own decisions and are well aware of the things which are good or bad for them. According to the some doctors and live examples it is seen that usually maturity comes at the age of 18 and the main thing to consider here is that is maturity comes from the social environment. All the social factors like relationship in society, working in society etc, helps in the attainment of complete genetic and the potential of human. But along with social environment there are factors which are known as individual environmental that affect the social behavior of human. There are various individual environmental factors that affect the human social behavior but the two most important environmental factors are physical environment and family environment factors. Physical environment: For child the physical environment includes the school environment and this environment includes the size of school and the size of classroom. The children who are more popular and rich normally enjoy high status and the popular children have the well developed role-taking skills. There are some people who are anxious and low in self esteem withdraw their contacts and which results in the bad impact on social relations. For example the children in school or college who are very aggressive prefer the normal children as their friend. (Steen, 2001) Family environment: The most important environmental factor and the socializing institution is family. With the birth of the child the parents starts taking care of his physical circumstance well being and not only the well being but also bring them up, educate them and this prepares them to contribute to the society. Parents have also influence on the aggression of their child and control on the aggression by parents helps the society to grow very much. So these two individual environmental factors affect the human social behavior. Inheritances also play important role like the cultural inheritance have more effects in comparison to the genetic inheritance and such cultural transmittance affects the development and behavior of human beings. There are two types of inheritances and they are cultural inheritance and the other one is genetic inheritance. The storage and communication of information, imitation and teaching refers to the cultural inheritance. The cultural inheritance is transmitted by brains where as the inheritance based on the genetic is known as genetic inheritance and these are not transmitted by brains and by genes. The genes involved in the cultural inheritance prepare the structure of brain where as in genetic inheritance all the things depends on genes. The latest stage which involves in the evolution of heredity is considered as cultural inheritance. There is a complete mechanism for the genetic inheritance and this mechanism give rise to the cultural inheritance. So cultural inheritance is better more important than the genetic because genetic behavior is permanent and there is no work of brain in this but in cultural every work is solved by brains which are transmitted by brain and this is not perm anent. The cultural transmittance affects the development as it helps in setting the mind and it gives the comparison between the good and worse. The behavior of human being like greed is also removed by cultural transmittance because this type of behavior of any person is not accepted by the culture and which results in the perfect growth and development of the human beings. But the most important factor which influences the growth and development of individual is the family environment. Discussions about the nurture and nature are also necessary for the human behavior. (Lerner, 2002) Both nature and nurture have great effects on the development of humans but here are some of the effects of nurture. Affect of nurture on the development of the individual means the factors which are environmental present around the individual which includes growing of the person and development on many levels. There are many factors included in the nurture and they are effect of family, schools, culture, media, society etc. Nurture has great effects on the development of a child and mostly on the students. The most important factor that affects greatly is the family atmosphere and the influence of family can make an individual perfect but the bad family atmosphere can ruin the life of the individual also. Most of the influences of the families are on career development of an individual which is more than the influence of school, work etc. For the college students like us who are given the great responsibility of decision making at the time of growing up and must be able to choose ea sily and get the job very easily. Members of the family help in making the atmosphere healthy by making it helpful and socially fit. It is because of family that that helps individuals to make social relations and helps in increasing their feelings towards everyone. As the technological resources are more with families as compared to students, family is considered for the support of the individual in career. (McCall, 2009) According to my survey majority is in favor of the change seen in the behavior while personally experiencing the world outside. It is the view of the most of the persons who interacted with the other people that this experience changed their attitude. Mostly the human behavior is affected by the nature of the human and a drastic change is seen in the ancient and the modern human behavior. The most important thing to know about human is nature and its influences on growth and functioning. Nature of an individual is the only thing which can give the idea that what kind of person heshe is. For example, if a person has honest and friendly nature then heshe will get every possible help during their bad time from their friends and family members. On the other hand if the person has a greedy or selfish nature then no one will like to help him and no one will like him as a friend. Person with good nature behaves in different manner and person with bad nature behaves in other manner. (Wormer, 2010) There are large number of differences between the ancient and the modern behaviors of humans. The modern human behavior is found in the type of language, religion, art, music, cooking etc. Due to the advancement in every field whether it is cultural, economic, political etc, the human behavior has also changed a lot. The people in the ancient times had so much social relations and they worked together in such a way that they had no selfishness and no greed of money. People in ancient times didnt even think of harming the others but the modern people dont even think about others and just think about themselves and how to make more and more money. According to the recent survey it was found that the modern people have 50% less social relations than ancient people. Modern people are harsh towards each other and they dont even think before giving harm to anyone. From all these points we can conclude that the behavior of modern people has changed a lot in comparison to ancient people. Alo ng with the nature evolutionary thinking also affects the behavior of humans and some other factors like socio-biological factors and psychological factors also contributes to it. Evolutionary thinking is the thinking which is based on the change in the inherited traits of the population of human beings through the successive generations and this change is the result of interaction between the processes that brings variations in the population. One of the greatest strength of this type of thinking is that it always helps in answering why question style in a fashion which can be scientific and non-metaphysical. Evolutionary thinking has great effects on the behavior of humans and it makes the person to take the decisions with great knowledge and matures that individual. Reflection of evolutionary thinking about health is the concept of natural healing. In this the psychological are also discussed and these factors are those factors that develops as the defense mechanisms and these factors are created when there are changes in the family environment of an individual and that includes restrictive, abusive and creating feelings of fear in the individuals. These fa ctors have a great impact on the behavior of human like the individual who faces all these problems become lonely and makes their behavior of cheating anyone etc. Socio-biological factors are the factors that mean the biological behavior for all social behavior. These factors are the biological or generic factors and they are operative in mate selection. This factor changes the behavior of human and makes their behavior common and mature. These are the relation between the evolutionary thinking and its effect on human behavior. (Hume, 2010) Result of Questionnaire- 1= Strongly Agree, 2= Agree, 3= Neutral, 4= Disagree, 5= Strongly Disagree. Questionnaire Results: 1 2 3 4 5 1. There is a change seen in your behavior while personally experiencing the world outside. 6 11 5 3 2. You gain skills or abilities while interacting with other people on your way. 10 11 1 3 3. Has this experience changed or affected your attitude. 10 10 4 1 4. There is improvement in your ambitions and knowledge. 11 9 3 1 1 5. There is any leadership qualities observed through your past experience. 4 9 11 1 6. There has been personality development in your behavior through experience. 7 13 3 1 1 7. There is any distraction seen in the focus and the concentration on work. 1 12 9 2 1 8. There has been adoption of ideas of different things that motivate you. 6 10 6 3 9. There is any goal set to achieve your target. 8 12 3 2 10. There is some learning attitude developed in you to understand the things better through your past experiences. 8 13 4 Conclusion- So as to conclude with the whole article we have created many of the bodies in order to throw light on the issue of the human social behavior which has influenced many of the social issues which are discussed. There is much importance of the social environment which is created in the development of the child which includes the achievement of the genetic and human potential. The Human behavior is changing with the increasing factors in the world where environmental factors of an individual also affect the behavior of a human being. There are discussions carried out to make the full description of the human social behavior and challenges which are faced by the company due to various kinds of human social behavior. We have defined the Human social behavior as the population which behaves influenced by the emotions, cultures, ethics, rapport and hypnosis which falls within a range of some behavior and some outside acceptable limits. There are various human natures provided which has adverse effect on the human behavior and many of the theories are mentioned in order to prove and justify the human behavior as changed. There is change in thinking which has been found in many of the humans that has greatly affected the human social behavior and attitude towards the other people and the other factors such as socio-biological; psychological factors also come into affect at the same time.

Antigone: The Conflict of Hubris, Fate, and The gods Essay -- Sophocle

Antigone: The Conflict of Hubris, Fate, and The gods Sophocles, Antigone is a classic example of the role of the gods in the life of a Grecian. It is a story of the precedent set by the gods, versus the will and actions of the characters of Antigone. Creon deceives himself into believing that he is upholding the laws set by the gods. While he would like to think of himself as being above the gods, even he can not deny their power. The humans were to revere the gods above all else, despite any obstacles that tried to displace them. Creon lies to himself to convince himself that he is not violating the laws of the gods. At first, Creon is able to ignore the edicts of the gods, because his beliefs lie shallowly within the boundaries of his mind, whereas Antigone’s reverence for the gods pierces the depths of her heart. In Antigone Creon falls victim to the tragic flaw of hubris, eventually leading the destruction of his house. Polynices and Etiocles were the rightful heirs to the thrown; however they were killed by mutual fratricide, a dishonorable way to kill and be killed. Creon’s only legitimate claim for the thrown of the house of Thebes would have been through Edipus; however, Edipus’ only claim to the thrown was the riddle of the sphinx. By Greek law this would not have transferred down to Creon, thus making his stake to the thrown an insecure one. Do to this, Creon has a plaguing fear of anarchy in his city. He wants to be a strong ruler, with no one questioning his authority, or challenging his power. This desire comes from a root of instability and illegitimacy. Creon’s first element of pride is to have a chorus that is loyal to him. If Creon could not even prove the legitimacy of his line to h... ... discusses the conflict between the will of the god’s versus the will of man, and what right Polynices even had to being buried. According to Greek culture, Creon had ever right to make a decree stating that Polynices need not be buried within city limits; however, he was going too far in his decree of no burial at all. The Irony is that in the end he ignores religion again, to have Polynices buried with the city limits, where the god’s would have wanted him outside of the city. There are many more elements of Grecian law and religion that this article discusses, and because of that this will definitely be a very helpful source. I can see many of the points that I was looking to make, backed up within this article. This article was an extremely helpful find. Works Cited Sophocles. Antigone Dover Thrift Editions New York: Dover Publications, INC. 1993

Glutinous Rice and Cocoa Powder

Tricia Bugarin Katruz Albano BUS 100 15 Aug 2011 Champorado: The Breakfast of Champions Champorado is a Filipino chocolate cereal made with sweet sticky rice much like the kind of rice you would use to make sushi. Filipinos consider this as the oatmeal or porridge that people eat in the morning. Champorado is considered to be the breakfast of champions because this type of food is cooked with cocoa powder and mixed with sugar which is guaranteed to give you an amazing burst of energy for a long period of time.Champorado originated back when the Spaniards colonized the Philippines in the late 1500’s during their galleon trades where Spanish ships sailed twice a year across the Pacific Ocean between the Philippines and Acapulco. A lot of the trades consist of silk, ceramics, and spices, and because of the frequent sailing, a lot of the Spaniards decided to stay in the Philippines bringing with them their familiarity of making Champorado. Over the century, this dish was made in m any different ways.It can be served for breakfast, or as a snack. You can also eat champorado when it’s cold after putting it in a fridge. Usually some Filipino eats the champorado with the combination of a dried fish. Although, it can be considered as a poor man’s food because it does not cost a lot of money and it is relatively easy to make. Everything you will need can be bought at your local grocery store. All you will need is a cup of sticky white rice, half a cup of unsweetened cocoa powder, two and a half cups of water, and half a cup of sugar.You can also add a little bit of vanilla extract but that is entirely up to you. You will, however, need evaporated milk which will give the Champorado a little bit of creme color and to get the thickness down before you start indulging in this delight. Cooking this dish is very simple and does not require a lot of math. Boil the cup of sticky white rice in a medium saucepan stirring constantly because you do not want the rice to clump up together. The rice is ready hen it is transparent and thicker in texture and consistency. Add your cocoa powder and the sugar mixing and stirring these ingredients together. Ones the cocoa powder and the sugar are well blended with the rice turn the heat off and put a little serving in a bowl. Now, you are ready to serve this delightful dish with a swirl of evaporated milk on top. You can typically serve Champorado hot or cold. In our culture, we serve this with a side of salty fish or meat for breakfast.Our society is one big melting pot of cultures where a lot of things are being introduced. It is okay to expose yourself to the many types of delicatessen available out there. The worst possible thing that can happen to you is a swollen throat or you can even break out in hives due to your allergies, so just be aware of the ingredients being used. Despite of the differences that we may have, we do have one thing in common; we all love to eat.

Lord Of The Flies Essays (391 words) - Conch, Strombidae, Symbols

Lord Of The Flies Essays (391 words) - Conch, Strombidae, Symbols Lord of the Flies Last Summer I spent a week in my Aunts cabin in northern Minnesota. One afternoon while swimming with my cousins in the lake, I had found a unique clam shell. It was silvery and rainbow like on the inside and creamy white on the outside. My little cousins enjoyed looking and playing with it the remaining part of the week. When it was time to leave they both wanted to keep the shell. The wanted to claim power over it by saying ?It?s mine!!? To resolve this dilemma I took the shell and tossed it far into the water. This action seemed to resolve the problem between the two boys, but then they both became mad at me! This is like how the conch played a important role in this story Lord of the Flies. A power struggle between two boys to gain control over someone ore something. In the beginning of this book the conch was regarded as having power and authority: ?I?ll[Ralph] give the conch to the next person to speak. He can hold it when he is speaking.? (Golding 33) The struggle of power in this book was very strong separation of the groups. The conch seemed to be the only common bond between the two groups. Even though Jacks? group was separate, when Ralph blew the conch in chapter 10 the boys on Jacks side came out and looked to see what was going on, they still believed in the power of the conch: ?He [Ralph] put the conch to his lips and began to blow. Savages appeared, painted out of recognition, edging round the ledge toward the neck. Ralph went on blowing and ignored Piggy?s terrors? (175). Once the conch was shattered into a million pieces, the dwindling power left in Ralph's group was completely gone, Piggy was dead and Sam n? Eric had converted to Jacks group of savages. Ralph was alone. Then unable to pick up the pieces, Ralph continued to endure the hatred and aggravation of Jacks savage society all by himself. Chased onto the beach, Ralph spotted a man, an officer from a naval ship. In short, this man represented the conch. He brought everyone left on the island together, in peace. The power between the children on the island had been resolved.

Mozambique-facts and figures essays

Mozambique-facts and figures essays Despite of the economic progress experienced in the late 1990s, Mozambique remains one of the poorest countries in the world, with 60 per cent of the population living below the poverty line. The problems facing Mozambique include: Economic benefits barely reach 80 per cent of the population living in rural areas The devastating consequences of the civil war The national emergency of HIV/AIDS is over stretching the pressure on already overstretched resources The ever growing external debt which diverts funds away from healthcare and education Continual dependence on foreign finance for development projects Natural hazards such as the year 2000 floods Immediately after independence in 1975 considerable progress was made, but these gains were mostly lost in the sixteen years of civil war and decades of disastrous natural hazards. As a result the Republic Of Mozambique is a severely underdeveloped country. Landmines still render travel outside the capital hazardous, while food shortages costly international flights, and poor infrastructure are added obstacles. Whilst it was destroyed by the civil war, it is slowly rebuilding and given political stability, Mozambique could yet exploit its excellent beaches and game reserves, which include the Gorongosa Game Park. There are plans afoot to incorporate reserves into South Africas much-visited Kruger Park, just across the boarder. Some foreign hotel groups are once more targeting Maputo as a luxury tourist and conference venue. In the 1970s the tourist industry drew some 300,000 South Africans and Rhodesians as visitors to the country. Another advantage was that its inflation has been low and foreign exchange rates relatively stable. Mozambiques economy grew at an annual 10% rate in 1997-99, one of the highest growth rates in the world. But this strength turned, growth slowed and inflation grew in 2000 due...

Madoff LLC Fraud Research Paper Example | Topics and Well Written Essays - 3000 words

Madoff LLC Fraud - Research Paper Example The founder and the president of the company was Mr. Bernard Madoff who used to invest the money for the hedge funds, institutions and wealthy people. It has further been found that the company that had been based in New York was the 23rd biggest market maker in the month of October, 2008 on NASDAQ. It was evident that the company handled approximately 50 million shares per day. The main activity of the company has been to handle the orders that the online brokers belonging to a few of the biggest US companies used to make such as the Citigroup Inc. and General Electric. It is evident that the company has been the foremost to mechanize market-making. In this type of dealing, the dealer tends to incessantly buy the stocks and sell them as well. Madoff’s firm has also been the biggest to offer â€Å"payment for order flow† (Glovin & Scheer, 2011). Bernard Madoff never revealed his financial statements and kept back them under his safe custody. Further, it has been noted t hat Madoff has also been one of the active members of the NASDAQ Stock Market related board of governors as well as the member of NASDAQ’s executive committee and also had been the Chairman of trading committee. It has been evident that greater than 75% of the firm that has been owned by Bernard Madoff, along with Peter Madoff who is his brother; were the only two persons who were recognized on the regulatory records, being the direct owners and the executive officers. The other family members operating for Madoff has been Peter Madoff’s daughter named Shana working as compliance attorney. Sons of Bernard Madoff namely Mark and Andrew, and Charles Weiner were in the trading section. Andrew invested his funds in the company, however he was stopped from doing so by Mark in the year 2001 (Glovin & Scheer, 2011). The company made use of the numerous marketing tactics for the purpose of drawing the customers and thus stimulating a new era where electronic trading was of pri ority. The company has been a highly profitable security firm tapping enormous volume of the stock trades from the Big Boards. The company during its initial days used to deal with the Over-The-Counter along with Pure-Brokerage-Pink Sheets transactions. It was because of the Rule 390, the company was able to trade in NYSE stocks. For the purpose of altering the execution practices, the company had to utilize the Cincinnati Stock Exchange. It has been evident that among the five brokers, Madoff has been one of them who had been involved in the creation of the NASDAQ. It was noted that the company’s spread was quite sublime. It started as an investment advisory firm. It has been noted that the company had not been recorded in the stock exchanges till 2006. It can be stated that in terms of the US Securities by the year 2000, Madoff Securities had been successful at becoming the top traders and had in approximation $300 million of assets (De La Merced, 2008). Three floors were o ccupied by the business of Lipstick Building. The 17th floor belonging to Lipstick Building was office of Bernard Madoff that had in approximation of less than 24 of the staffs. It has been found that only a few of the employees were allowed to enter into that building. The floor was named as the hedge fund floor (Henriques & Berenson, 2008).  

Ultimate fighting championship Essay Example | Topics and Well Written Essays - 500 words

Ultimate fighting championship - Essay Example Since UFC is spreading its vision to digital platforms, there are a lot of career opportunities for affiliate marketers, as UFC continues to enter into partnerships with advanced distribution partners, like Xbox and Play Station. Jobs are available for the management of affiliate marketing relationships with these distribution partners. Opportunities are also available in UFC sales and marketing department for carrying out corporate sponsorship sales. The job of a senior director in UFC sales and marketing will be to generate revenue by advertising the portfolio of UFC international entities. He will also be responsible for gaining scholarships and building business relationships with high-profile corporate partners. Market research coordinators are also required in UFC. A market research coordinator will be responsible for regularly coordinating and managing research projects regarding event planning, sponsorship, public relations, advertising, marketing through digital media, and o ther company divisions. Other career opportunities are present for Digital Marketing Partnerships Manager, General Manager, Digital Marketing Manager, Human Resources Manager, Recruiter, Digital Media Analyst, Digital Media Affiliate Marketing Manager, and Cost Accountant (Simply Hired, Inc.). This shows that UFC offers a vast variety of career opportunities. As far as goals and objectives are concerned, UFC aims to train best fighters in the world, while giving innovations to its programs and events. It also aims to go into business partnerships with high-end distribution partners. Since it is the fastest developing sports organization in the whole wide world, it aims to promote mixed martial arts at a global level. It also aims to arrange tournaments of highly skilled athletes in various disciplines of martial arts including karate, jiu-jitsu, kickboxing, boxing, wrestling, grappling, sumo and various other fighting sports. UFC has another